Single Sided Magnetic Particle Imaging

Most of the published MPI scanner use a setup, where the field of view lies in between a symmetric coil configuration. This, however, poses a size limitation for the specimens. In this project, we present a feasibility study of a new, so-called single-sided scanner, which is applied to the object of interest merely from one side. Thus, the problem of the specimen fitting into the scanner no longer exists, which denotes a major step for MPI. To date, the FOV of the Single Sided device is limited to two dimensions. First one dimension experimental results on imaging phantoms containing a super paramagnetic fluid show a resolution of up to 1 mm and are indeed promising.

The Single Sided setup for 2D imaging consists of two concentric circular coils and on D-shaped coil pair and is constructed at the Institute. One of its medical application scenarios is the detection of the sentinel lymph node. Super-paramagnetic iron oxide nanoparticles (SPIONs) are used as tracer material and will be injected into the breast tumour. Via the lymphatic system, the SPIONs reach the sentinel lymph node, which will be detected and accurately located with the Single Sided MPI scanner.

Single Sided MPI Scanner at the Institute of Medical Engineering.

Grants

  • Damp-Stiftung - Press release
  • Federal Ministry of Education and Research under grant number BMBF 01EZ0912.

Cooperations

 

Publications

2022[ to top ]
  • Volkens, H., Blancke Soares, Y., Buzug, T. M. and Gräfe, K.: An Algorithm for computing optimal SNR-thresholds of a single-sided FFP MPI device, Vol 8 No 1 Suppl 1 (2022), 2022, DOI: 10.18416/IJMPI.2022.2203043.
2020[ to top ]
  • Blancke Soares, Y., Gräfe, K., Lüdtke-Buzug, K. and Buzug, T. M.: Investigation of the spatial resolution and penetration depth of a single-sided MPI device in three-dimensional imaging, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009053.
  • Gräfe, K. and Buzug, T. M.: Simulation study to minimize the single-sided FFP MPI scanner, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009047.
2019[ to top ]
  • Blancke Soares, Y., Gräfe, K., von Gladiss, A., Debbeler, C., Lüdtke-Buzug, K. and Buzug, T. M.: Verification of the Linear System Response of a Single-Sided MPI Device, 51–52, 2019.
  • von Gladiss, A., Blancke Soares, Y., Buzug, T. M. and Gräfe, K.: Dynamic Imaging with a 3D Single-Sided MPI Scanner, 235–236, 2019.
2018[ to top ]
  • Gräfe, K., von Gladiss, A. and Buzug, T. M.: First Phantom Measurements with a 3D Single Sided MPI Scanner, 2018.
2016[ to top ]
  • Gräfe, K., von Gladiss, A., Ahlborg, M., Bringout, G. and Buzug, T. M.: Reconstruction of a 2D Phantom Recorded with a Single-Sided MPI Device, 23, 2016.
  • Blancke Soares, Y., von Gladiss, A., Ahlborg, M., Gräfe, K. and Buzug, T. M.: Comparison of Frequency Selection Methods for Image Reconstruction in Magnetic Particle Imaging - Improving Image Quality -, 221–224, 2016.
  • Gräfe, K., von Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T.: 2D Images Recorded With a Single-Sided Magnetic Particle Imaging Scanner, IEEE Transactions on Medical Imaging, 35(4), 1056–1065, 2016, DOI: 10.1109/TMI.2015.2507187.
  • Weissert, P., von Gladiss, A. and Buzug, T. M.: Comparing Different Compressed Sensing Reconstruction Techniques for the System Matrix in Single-Sided MPI, 225–228, 2016.
  • Gräfe, K.: Bildgebungskonzepte für Magnetic Particle Imaging Magnetic Particle Imaging mit einer asymmetrischen Spulentopologie, Infinite Science Publishing, Lübeck, 2016, ISBN: 978-3-945954-27-0.
  • Bringout, G., Gräfe, K. and Buzug, T. M.: MPI System Matrix Reconstruction: Making Assumptions on the Imaging Device rather than on the Tracer Spatial Distribution, 174, 2016.
2015[ to top ]
  • v. Gladiß, A., Gräfe, K., Ahlborg, M. and Buzug, T.: Undersampling the system matrix of a single sided MPI-scanner, 2015, DOI: 10.1109/IWMPI.2015.7107021.
  • Finas, D., Stegemann-Frehse, J., Sauer, B., Hüttmann, G., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO processing in macrophages for MPI - the breast cancer MPI-SNLB-concept, 228, 2015, DOI: 10.1515/bmt-2015-5010.
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. and Buzug, T.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, IEEE Transactions on Magnetics, 51(2), 6502303, 2015, DOI: 10.1109/TMAG.2014.2330371.
  • Gräfe, K., v. Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T. M.: 2D Imaging with a Single-Sided MPI Device, 2015, DOI: 10.1109/IWMPI.2015.7107024.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. and Lüdtke-Buzug, K.: SPIO Detection and Distribution in Biological Tissue - A Murine MPI-SLNB Breast Cancer Model, IEEE Transactions on Magnetics, 51(2), 5400104, 2015, DOI: 10.1109/TMAG.2014.2358272.
2014[ to top ]
  • Finas, D., Baumann, K., Stegemann-Frehse, J., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: Processing of nanoparticles in organism - further development of the breast cancer SNLB-concept using SPIOs and MPI, 314, 2014, DOI: 10.1515/bmt-2014-41.
  • Baumann, K., Stegmann-Frehse, J., Rody, A., Gräfe, K., Lüdtke-Buzug, K., Buzug, T. and Finas, D.: Weiterentwicklung des SNLB-Konzept unter Verwendung von SPIOs beim Mammakarzinom - Prozessierung der Nanopartikel im Organismus, Senologie, 11-A13, 2014, DOI: 10.1055/s-0034-1375372.
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. F. and Buzug, T. M.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, 92, 2014.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO detection and distribution in biological tissue – a murine MPI-SNLB breast cancer model, 166, 2014.
2013[ to top ]
  • Gräfe, K., Grüttner, M., Sattel, T., Kaethner, C. and Buzug, T.: Phantom simulation based on measured gradient fields of a single-sided MPI scanner, 2013, DOI: 10.1109/IWMPI.2013.6528352.
  • Gräfe, K., Weber, M., Sattel, T. and Buzug, T.: Precision of an MPI Scanner Construction: Registration of Measured and Simulated Magnetic Fields, 2013, DOI: 10.1515/bmt-2013-4258.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T.: Lymphatic Tissue and Superparamagnetic Nanoparticles - Magnetic Particle Imaging for Detection and Distribution in a Breast Cancer Model, 2013, DOI: 10.1515/bmt-2013-4262.
  • Mrongowius, J., Gräfe, K. and Buzug, T. M.: Simulation Study of a Single-Sided Magnetic Particle Imaging Device, 2013, DOI: 10.1515/bmt-2013-4285.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T.: Superparamagnetic nanoparticles in lymphatic tissue - Detection and distribution in a breast cancer model for magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528390.
  • Gräfe, K., Grüttner, M., Sattel, T. F., Graeser, M. and Buzug, T. M.: Single-sided magnetic particle imaging: magnetic field and gradient, 867219, 2013, DOI: 10.1117/12.2001610.
2012[ to top ]
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Buzug, T. and Lüdtke-Buzug, K.: Detection and distribution of superparamagnetic nanoparticles in lymphatic tissue in a breast cancer model for magnetic particle imaging, 81–83, 2012, DOI: 10.1515/bmt-2012-4158.
  • Finas, D., Baumann, K., Heinrich, K., Ruhland, B., Sydow, L., Gräfe, K., Sattel, T. F., Lüdtke-Buzug, K. and Buzug, T. M.: Distribution of Superparamagnetic Nanoparticles in Lymphatic Tissue for Sentinel Lymph Node Detection in Breast Cancer by Magnetic Particle Imaging, 187–191, 2012, DOI: 10.1007/978-3-642-24133-8_30.
  • Gräfe, K., Sattel, T., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T.: Magnetic-Particle-Imaging for Sentinel Lymph Node Biopsy in Breast Cancer, 237–241, 2012, DOI: 10.1007/978-3-642-24133-8_38.
  • Gräfe, K., Sattel, T., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T.: An Application Scenario for Single-Sided Magnetic Particle Imaging, 514, 2012, DOI: 10.1515/bmt-2012-4343.
2010[ to top ]
  • Sattel, T. F., Biederer, S., Knopp, T. and Buzug, T. M.: Magnetic Field Generation For Multi-Dimensional Single-Sided Magnetic Particle Imaging, 3297, 2010.
  • Finas, D., Ruhland, B., Baumann, K., Knopp, T., Sattel, T., Biederer, S., Lüdtke-Buzug, K., Buzug, T. and Diedrich, K.: Sentinal Lymphnode Detection in Breast Cancer by Magnetic Particle Imaging Using Superparamagnetic Nanoparticles, 35, 2010, DOI: 10.1142/9789814324687_0029.
  • Sattel, T., Knopp, T., Biederer, S., Erbe, M., Lüdtke-Buzug, K. and Buzug, T.: Resolution Distribution in Single-Sided Magnetic Particle Imaging, 106–112, 2010, DOI: 10.1142/9789814324687_0015.
2009[ to top ]
  • Sattel, T. F., Biederer, S., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Borgert, J. and Buzug, T. M.: Hand-Held Concept of a Magnetic Particle Imaging Device, J521, 2009.
  • Sattel, T., Biederer, S., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T.: Single-Sided Coil Configuration for Magnetic Particle Imaging, 281–284, 2009, DOI: 10.1007/978-3-642-03885-3_78.
  • Sattel, T. F., Knopp, T., Biederer, S., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: Single-Sided Device for Magnetic Particle Imaging, Journal of Physics D: Applied Physics, 42(2), 022001, 2009.