SAMBA PATI (Smart Application of Magnetic-Based Particle Therapy and Imaging)

The development of Magnetic Particle Imaging (MPI), as a tool for new possibilities in the field of medical diagnostics, has been driven forward in the past years. However, the magnetic nanoparticles that are used as a tracer material in MPI are used as a therapeutic drug in other medical applications. In this project, the combination of therapy and diagnostics with MPI is performed.

The focus in our institute within the strong collaboration will be on two main parts. First, the evaluation of magnetic nanoparticle characteristics that are needed for the combined use in imaging and therapy of MPI. Second, the design, the integration, and the validation of an MPI-HIFU (High Intensity Focused Ultrasound) thermotherapy device.

 

Concept of a theranostic device as inlay for an MPI scanner

Grants

  • Federal Ministry of Education and Research under grant number BMBF 13GW0069A

Cooperations

  • Philips Medical Systems DMC GmbH
  • University of Bochum
  • Bruker BioSpin

Publications

2020[ to top ]
  • Neumann, A. and Buzug, T. M.: Simulations of magnetic particles with arbitrary anisotropies, International Journal on Magnetic Particle Imaging, 6(2), Suppl. 1, 2009032, 2020, DOI: 10.18416/IJMPI.2020.2009032.
  • Klemme, T., Buzug, T. M. and Neumann, A.: Exploring Parameters of Magnetic Particles in 1D Field Excitation, International Journal on Magnetic Particle Imaging, 6(2), 2004001, 2020, DOI: 10.18416/IJMPI.2020.2004001.
  • Chen, X., Behrends, A., Malhotra, A., Neumann, A. and Buzug, T. M.: Temperature-dependent spectrum measurement using a magnetic particle spectrometer, International Journal on Magnetic Particle Imaging, 6(2), Suppl 1, 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009034.
2019[ to top ]
  • Behrends, A., Wei, H., Friedrich, T., Neumann, A. and Buzug, T. M.: A self-compensating coil setup for combined magnetic particle imaging and magnetic fluid hyperthermia, 2019.
  • Chen, X., Behrends, A., Neumann, A. and Buzug, T. M.: Sample Temperature Control in a Three-Dimensional Magnetic Particle Spectrometer, 211, 2019.
  • Klemme, T., Buzug, T. M. and Neumann, A.: Exploring parameters of magnetic particles in 1D field excitation, 189, 2019.
  • Malhotra, A., von Gladiss, A., Behrends, A., Friedrich, T., Neumann, A., Buzug, T. M. and Lüdtke-Buzug, K.: Tracking the Growth of Superparamagnetic Nanoparticles with an In-Situ Magnetic Particle Spectrometer (INSPECT), Scientific Reports, 9(10538), 2019, DOI: https://doi.org/10.1038/s41598-019-46882-6.
  • Neumann, A., Draack, S., Ludwig, F. and Buzug, T. M.: Parameter estimations of magnetic particles: A comparison between measurements and simulations, 79, 2019.
2018[ to top ]
  • Chen, X., Graeser, M., Behrends, A., von Gladiss, A. and Buzug, T. M.: First Measurement and SNR Results of a 3D Magnetic Particle Spectrometer, International Journal on Magnetic Particle Imaging, 4(1), 2018, DOI: 10.18416/IJMPI.2018.1810001.
  • Behrends, A., Buzug, T. M. and Neumann, A.: Design of a Switched-Capacitor Array for High-Power Applications with Dense Coverage of Medium Frequency-Range, 171–172, 2018.
  • Chen, X., Neumann, A. and Buzug, T. M.: Optimizing Transmit Coils for a Magnetic Particle Spectrometer, 161, 2018.
  • Wegner, F., Friedrich, T., Panagiotopoulos, N., Valmaa, S., Goltz, J. P., Vogt, F. M., Koch, M. A., Buzug, T. M., Barkhausen, J. and Haegele, J.: First heating measurements of endovascular stents in magnetic particle imaging, Physics in Medicine and Biology, 63(4), 045005, 2018, DOI: 10.1088%2F1361-6560%2Faaa79c.
  • Aderhold, E., Buzug, T. M. and Friedrich, T.: An Acoustic Magnetic Particle Spectrometer, 115, 2018.
  • Neumann, A. and Buzug, T. M.: Stochastic simulations of magnetic particles: Comparison of different methods, 213, 2018.
  • Kranemann, T. C., Ersepke, T., Franke, J., Friedrich, T., Neumann, A., Buzug, T. M. and Schmitz, G.: An MPI-Compatible HIFU Transducer: Experimental Evaluation of Interferences, 197, 2018.
2017[ to top ]
  • Chen, X., Graeser, M., Behrends, A., von Gladiss, A. and Buzug, T. M.: First measured result of the 3D Magnetic Particle Spectrometer, 123, 2017.
  • Jacobi, C., Friedrich, T. and Lüdtke-Buzug, K.: Synthesis and Characterisation of Superparamagnetic Polylactic acid based Polymers, International Journal on Magnetic Particle Imaging, 3(2), 1710001, 2017, DOI: 10.18416/ijmpi.2017.1710001.
2016[ to top ]
  • Behrends, A., Buzug, T. M. and Neumann, A.: Magnetic Particle Spectrometer for the Analysis of Magnetic Particle Heating Applications, 47, 2016.
  • Nothnagel, N., Rahmer, J., Gleich, B., Halkola, A., Buzug, T. and Borgert, J.: Steering of Magnetic Devices with a Magnetic Particle Imaging System, IEEE Transactions on Biomedical Engineering, PP(99), 7396945, 2016, DOI: 10.1109/TBME.2016.2524070.
  • Weller, D., Buzug, T. M. and Friedrich, T.: Force analysis device for magnetic manipulation, 2016.
  • Chen, X., Behrends, A., Graeser, M., Neumann, A. and Buzug, T. M.: Optimizing the Coil Setup for a Three-Dimensional Magnetic Particle Spectrometer, 59, 2016.
2015[ to top ]
  • Graeser, M., Bente, K., Neumann, A. and Buzug, T. M.: Trajectory Dependent Particle Response for Anisotropic Mono Domain Particles in Magnetic Particle Imaging, Journal of Physics D: Applied Physics, 49(4), 2015, DOI: 10.1088/0022-3727/49/4/045007.
  • Graeser, M., Bente, K. and Buzug, T. M.: Dynamic Single-Domain Particle Model for Magnetite Particles with Combined Crystalline and Shape Anisotropy, Journal of Physics D: Applied Physics, 48(27), 275001, 2015, DOI: 10.1088/0022-3727/48/27/275001.
  • Graeser, M., Ahlborg, M., Behrends, A., Bente, K., Bringout, G., Debbeler, C., v. Gladiß, A., Gräfe, K., Kaethner, C., Kaufmann, S., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Weber, M. and Buzug, T. M.: A Device for Measureing the Trajectorey Dependent Magnetic Particle Performance for MPI, 2015, DOI: 10.1109/IWMPI.2015.7107078.
  • Behrends, A., Graeser, M. and Buzug, T. M.: Introducing a frequency-tunable magnetic particle spectrometer, 249–253, 2015, DOI: 10.1515/cdbme-2015-0062.
2013[ to top ]
  • Nothnagel, N., Rahmer, J., Gleich, B., Halkola, A., Borgert, J. and Buzug, T. M.: Steering of magnetic devices with a magnetic particle imaging system, 6528358, 2013, DOI: 10.1109/IWMPI.2013.6528358.