LUMEN: Institute of Medical Engineering

LUMEN (Luebeck Medical Engineering)

In urgent emergencies of the brain (stenosis, vascular deficiencies, aneurysms, etc.), 2D-DSA is the clinical standard. Unfortunately, this is only a qualitative method. The actual amount of blood flow and oxygen supply cannot be determined. To analyze the dynamics of the contrast bolus and embed in the 3D vessel topology, magnetic particle imaging (MPI) is used in this project. A novel MPI system is built making it possible to track the bolus of contrast agent in real time. This is based on a field-free line (FFL). The MPI image does not include any native tissue and requires a registration with the static 3D rotational angiography.

In this project most of the engineering is done in our lab. We build customized coils for the scanner, specialized filter hardware, shielding techniques and phantoms. Our aim is a real time MPI scanner featuring the field-free line technology.

Field-free line scanner at the Institute of Medical Engineering.

Grants

Federal Ministry of Education and Research under grant number BMBF 13EZ1140A

Cooperations

Prof. Dr. rer. nat. Henrik Botterweck (Institut für Medizinische Bildgebung, Fachochschule Lübeck)
Prof. Dr. med Dirk Petersen (Institut für Neuroradiologie, Universität zu Lübeck)
Dr.-Ing. Markus Kowarschik (Siemens Healthcare, Imaging & IT Division)

Publications

[ 2018 ]
[ 2015 ]
[ 2014 ]
[ 2013 ]

2018[ to top ]

Weber, M., Beuke, J., von Gladiss, A., Gräfe, K., Vogel, P., Behr, V. C. and Buzug, T. M.: Novel Field Geometry Using Two Halbach Cylinders for FFL-MPI, International Journal on Magnetic Particle Imaging, 4(1), 2018, DOI: 10.18416/IJMPI.2018.1811004.
- [ BibTeX ]
- [ URL ]
@article{weber20182016novel, abstract = {Magnetic Particle Imaging (MPI) offers several methods for encoding magnetic materials in three-dimensions. The complexity of the imaging device in MPI using a field free line (FFL) is the biggest challenge in realizing such devices. This is especially the case for systems featuring large bores, high gradients or high temporal resolution. In this work, we suggest a novel Halbach cylinder based field generator that is able to generate an FFL with a gradient of 5 T/m. By rotating the Halbach array, FFL projections can be acquired. Furthermore, just one static drive field coil is needed for two-dimensional imaging. The presented concept could combine high gradient strength and high temporal resolution with minimum space requirements for FFL-MPI imaging in the future. Int. J. Mag. Part. Imag. 4(2), 2018, Article ID: 1811004, DOI: 10.18416/IJMPI.2018.1811004}, author = {Weber, Matthias and Beuke, Jonas and von Gladiss, Anselm and Gräfe, Ksenija and Vogel, Patrick and Behr, Volker C. and Buzug, Thorsten M.}, journal = {International Journal on Magnetic Particle Imaging}, keywords = {buzugthorsten}, number = 1, title = {Novel Field Geometry Using Two Halbach Cylinders for FFL-MPI}, type = {Text.Serial.Journal}, volume = 4, year = 2018 }

2015[ to top ]

Weber, M., Bente, K., Graeser, M., Sattel, T. F. and Buzug, T. M.: Implementation of a High-Precision 2-D Receiving Coil Set for Magnetic Particle Imaging, IEEE Transactions on Magnetics, 51(2), 6502404, 2015, DOI: 10.1109/TMAG.2014.2331987.
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@article{Weber2014b, abstract = {In the medical imaging technique magnetic particle imaging, tomographic images of the spatial distribution of superparamagnetic particles are produced in real time. To generate images in a plane, the particles are excited in two dimensions. A specific particle response can be measured via receiving coils and the measured signal gives quantitative information about the particle distribution and local concentration. To achieve a high-spatial resolution with x-space reconstruction, the receiving coils have to feature a preferably homogeneous sensitivity in the field of view. To achieve this for a cylindrical bore, which is the typical medical scenario, an optimized coil set is implemented and tested in this paper. Two orthogonal receiving coil pairs are wound inside a negative form, which is custom made by a 3-D printer. Further, a well performing receiving chain is utilized, which transmits the particle signal from the receiving coils to the data acquisition unit. For performance evaluation, a hardware phantom with three delta samples is used. A field free line is chosen as a selection field, for which the presented coils may be used in an application scenario. The receiving coils perform well in the sense that no coupling in between the data paths is apparent and the recorded signals clearly represent the used phantom.}, author = {Weber, M. and Bente, K. and Graeser, M. and Sattel, T. F. and Buzug, T. M.}, journal = {IEEE Transactions on Magnetics}, keywords = {WeberMatthias}, month = {02}, number = 2, pages = 6502404, title = {Implementation of a High-Precision 2-D Receiving Coil Set for Magnetic Particle Imaging}, volume = 51, year = 2015 }

2014[ to top ]

Weber, M., Bente, K. and Buzug, T. M.: Insight in Scanner Construction for a Dynamical Field Free Line for Magnetic Particle Imaging, 2014.
- [ BibTeX ]
@inproceedings{Weber2014c, author = {Weber, M. and Bente, K. and Buzug, T. M.}, booktitle = {Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung}, keywords = {WeberMatthias}, title = {Insight in Scanner Construction for a Dynamical Field Free Line for Magnetic Particle Imaging}, year = 2014 }
Bente, K., Weber, M., Graeser, M., Sattel, T. F., Erbe, M. and Buzug, T. M.: Electronic Field Free Line Rotation and Relaxation Deconvolution in Magnetic Particle Imaging, IEEE Transactions on Medical Imaging, 34(2), 644–651, 2014, DOI: 10.1109/TMI.2014.2364891.
- [ BibTeX ]
- [ URL ]
@article{Bente2014a, abstract = {It has been shown that magnetic particle imaging (MPI), an imaging method suggested in 2005, is capable of measuring the spatial distribution of magnetic nanoparticles. Since the particles can be administered as biocompatible suspensions, this method promises to perform well as a tracer-based medical imaging technique. It is capable of generating real-time images, which will be useful in interventional procedures, without utilizing any harmful radiation. To obtain a signal from the administered superparamagnetic iron oxide (SPIO) particles, a sinusoidal changing external homogeneous magnetic field is applied. To achieve spatial encoding, a gradient field is superimposed. Conventional MPI works with a spatial encoding field that features a field free point (FFP). To increase sensitivity, an improved spatial encoding field, featuring a field free line (FFL) can be used. Previous FFL scanners, featuring a 1-D excitation, could demonstrate the feasibility of the FFL-based MPI imaging process. In this work, an FFL-based MPI scanner is presented that features a 2-D excitation field and, for the first time, an electronic rotation of the spatial encoding field. Furthermore, the role of relaxation effects in MPI is starting to move to the center of interest. Nevertheless, no reconstruction schemes presented thus far include a dynamical particle model for image reconstruction. A first application of a model that accounts for relaxation effects in the reconstruction of MPI images is presented here in the form of a simplified, but well performing strategy for signal deconvolution. The results demonstrate the high impact of relaxation deconvolution on the MPI imaging process.}, author = {Bente, K. and Weber, M. and Graeser, M. and Sattel, T. F. and Erbe, M. and Buzug, T. M.}, journal = {IEEE Transactions on Medical Imaging}, keywords = {WeberMatthias}, month = {02}, number = 2, pages = {644-651}, title = {Electronic Field Free Line Rotation and Relaxation Deconvolution in Magnetic Particle Imaging}, volume = 34, year = 2014 }
Weber, M., Bente, K., Graeser, M., Sattel, T. F. and Buzug, T. M.: Technical Aspects of a Two Dimensional Rotatable Field Free Line Imager for Magnetic Particle Imaging, 98, 2014.
- [ BibTeX ]
@inproceedings{Weber2014a, author = {Weber, M. and Bente, K. and Graeser, M. and Sattel, T. F. and Buzug, T. M.}, booktitle = {International Workshop on Magnetic Particle Imaging}, keywords = {WeberMatthias}, pages = 98, title = {Technical Aspects of a Two Dimensional Rotatable Field Free Line Imager for Magnetic Particle Imaging}, year = 2014 }

2013[ to top ]

Weber, M., Erbe, M., Bente, K., Sattel, T. and Buzug, T.: Scanner Construction for a Dynamic Field Free Line in Magnetic Particle Imaging, 2013, DOI: 10.1515/bmt-2013-4259.
- [ BibTeX ]
- [ URL ]
@inproceedings{Weber2013b, author = {Weber, M. and Erbe, M. and Bente, K. and Sattel, T.F. and Buzug, T.M.}, booktitle = {Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung}, keywords = {WeberMatthias}, title = {Scanner Construction for a Dynamic Field Free Line in Magnetic Particle Imaging}, volume = 58, year = 2013 }
Weber, M., Erbe, M., Bente, K., Sattel, T. and Buzug, T.: Power loss optimized field free line generation for magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528354.
- [ BibTeX ]
- [ URL ]
@inproceedings{Weber2013a, abstract = {First magnetic field measurements look promising and show excellent agreement with simulations. Power loss optimization realizes FFL imaging at moderate cooling effort. The gain of sensitivity is directly going to improve image quality. The next step is the complete scanner assembling.}, author = {Weber, M. and Erbe, M. and Bente, K. and Sattel, T.F. and Buzug, T.M.}, booktitle = {International Workshop on Magnetic Particle Imaging}, keywords = {WeberMatthias}, month = {03}, title = {Power loss optimized field free line generation for magnetic particle imaging}, year = 2013 }
Erbe, M., Weber, M., Sattel, T. F. and Buzug, T. M.: Experimental Validation of an Assembly of Optimized Curved Rectangular Coils for the use in Dynamic Field Free Line Magnetic Particle Imaging, Current Medical Imaging Reviews, 9(2), 89–95, 2013, DOI: 10.2174/1573405611309020003.
- [ BibTeX ]
- [ URL ]
@article{Erbe:2013a, author = {Erbe, M. and Weber, M. and Sattel, T. F. and Buzug, T. M.}, journal = {Current Medical Imaging Reviews}, keywords = {WeberMatthias}, number = 2, pages = {89-95}, title = {Experimental Validation of an Assembly of Optimized Curved Rectangular Coils for the use in Dynamic Field Free Line Magnetic Particle Imaging}, volume = 9, year = 2013 }