Dr.-Ing. Ksenija Gräfe

Photo of Ksenija Gräfe

Institut für Medizintechnik
Universität zu Lübeck
Ratzeburger Allee 160
23562 Lübeck
Gebäude 64, Raum 052

Email: ksenija.graefe(at)uni-luebeck.de
Phone: +49 451 3101 5424
Fax: +49 451 3101 5404

Role

Research Scientist
 

Research

Research Interests

  • Magnetic Particle Imaging (MPI)
  • Biomedical Signal Processing

Involved Projects

  • Magnetic Particle Imaging

Current Aspects of Research

  • Improving the single-sided MPI scanner
  • Comparing different simulation tools

Teaching

Involved Lectures, Seminars and Courses

Further activities

Associate Editor

  • Student Conference Proceedings 2022, Infinite Science GmbH, Lübeck, 2022, ISBN: 978-3-945954-67-6
  • Student Conference Proceedings 2021, Infinite Science GmbH, Lübeck, 2021, ISBN: 978-3-945954-65-2
  • Student Conference Proceedings 2020, Infinite Science GmbH, Lübeck, 2020, ISBN: 978-3-945954-62-1
  • Student Conference Proceedings 2019, Infinite Science GmbH, Lübeck, 2019, ISBN: 978-9-945954-57-7
  • Student Conference Proceedings 2018, Infinite Science GmbH, Lübeck, 2018, ISBN: 978-9-945954-47-8

Curriculum Vitae

KSENIJA GRÄFE was born in Düsseldorf, Germany in 1986. In 2009 she received her B.Sc. in Electrical Engineering and Information Technology from the University of Duisburg-Essen, Germany. In 2009 she wrote her bachelor thesis at the Fraunhofer Institute for Microelectronic Circuits and Systems. She received her M.Sc. in Biomedical Engineering from the Leibniz University Hannover, Germany, in 2011. In 2010/2011 she finished her university studies with the master thesis, which she wrote at the Institute of Biomedical Engineering, Karlsruhe. Since 08/2011 she joined the Magnetic Particle Imaging (MPI) group as a research assistant at the Institute of Medical Engineering, Lübeck. She received her PhD in 2016.

Additionally, she is part of the Lübecker IngenieurInnen Labor (LILa), which aims at raising interest of high school students for the field of science and technology, especially medical engineering.

Publications

2022[ to top ]
  • Neumann, A., Gräfe, K., von Gladiss, A., Ahlborg, M., Behrends, A., Chen, X., Schumacher, J., Soares, Y. B., Friedrich, T., Wei, H., Malhorta, A., Aderhold, E., Bakenecker, A. C., Lüdtke-Buzug, K. and Buzug, T. M.: Recent developments in magnetic particle imaging, Journal of Magnetism and Magnetic Materials, 550, 169037, 2022, DOI: 10.1016/j.jmmm.2022.169037.
  • Stelzner, J., Bakenecker, A., Behrends, A., Bringout, G., Chen, X., von Gladiss, A., Gräfe, K., Schumacher, J. and Buzug, T.: Implementation and imaging with a versatile 180 mm magnetic particle imaging field generator, Journal of Magnetism and Magnetic Materials, 169509, 2022, DOI: 10.1016/j.jmmm.2022.169509.
  • Volkens, H., Blancke Soares, Y., Buzug, T. M. and Gräfe, K.: An Algorithm for computing optimal SNR-thresholds of a single-sided FFP MPI device, Vol 8 No 1 Suppl 1 (2022), 2022, DOI: 10.18416/IJMPI.2022.2203043.
  • Gräser, M., Wegner, F., Schumacher, J., Ahlborg, M., Gräfe, K., Aderhold, E., Soares, Y. B., Lüdtke-Buzug, K., Neumann, A., Stagge, P., Wei, H., Ackers, J. and Buzug, T. M.: Magnetic particle imaging, Die Radiologie, 62(6), 496–503, 2022, DOI: 10.1007/s00117-022-01011-9.
2021[ to top ]
  • Behrends, A., Bakenecker, A., Ahlborg, M., Gräfe, K., Schumacher, J., Stelzner, J., Wegner, F., Neumann, A., Blancke Soares, Y., Lüdtke-Buzug, K., Chen, X., Wei, H., Malhotra, A., Friedrich, T. and Buzug, T. M.: Magnetic particle imaging, In: Imaging Modalities for Biological and Preclinical Research: A Compendium, IOP Publishing, , II.8–1 to II.8, 2021, DOI: 10.1088/978-0-7503-3747-2ch12.
  • Blancke Soares, Y., Lüdtke-Buzug, K., Von Gladiss, A., Debbeler, C., Buzug, T. M. and Gräfe, K.: Further system characterization of the Single-Sided MPI Scanner with two- and three-dimensional measurements, International Journal on Magnetic Particle Imaging, Vol 7 No 2 (2021), 2021, DOI: 10.18416/IJMPI.2021.2109001.
2020[ to top ]
  • Bakenecker, A. C., Schumacher, J., Blümler, P., Gräfe, K., Ahlborg, M. and Buzug, T. M.: A concept for an MPI scanner with Halbach arrays, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: 10.18416/IJMPI.2020.2009008.
  • Stelzner, J., Gräfe, K. and Buzug, T. M.: First images obtained with a rabbit-sized Magnetic Particle Imaging scanner, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009033.
  • Schumacher, J., Malhotra, A., Gräfe, K. and Buzug, T. M.: Highly symmetric filter for a fully differential receive chain, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: 10.18416/IJMPI.2020.2009031.
  • Blancke Soares, Y., Gräfe, K., Lüdtke-Buzug, K. and Buzug, T. M.: Investigation of the spatial resolution and penetration depth of a single-sided MPI device in three-dimensional imaging, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009053.
  • Bakenecker, A. C., Schumacher, J., Blümler, P., Gräfe, K., Ahlborg, M. and Buzug, T. M.: A concept for a magnetic particle imaging scanner with Halbach arrays, Physics in Medicine and Biology, 65(19), 2020, DOI: 10.1088/1361-6560/ab7e7e.
  • Gräfe, K. and Buzug, T. M.: Simulation study to minimize the single-sided FFP MPI scanner, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009047.
2019[ to top ]
  • Stelzner, J., Gräfe, K., von Gladiss, A., Beuke, J. and Buzug, T. M.: A Rabbit Sized Field-Free-Line Magnetic-Particle-Imaging Scanner - Past, Present, and Future, 239, 2019.
  • Beuke, J., Weber, M., von Gladiss, A., Vogel, P., Behr, V. C., Gräfe, K. and Buzug, T. M.: Halbach-Based Field-Free Line MPI Scanner, 2019.
  • von Gladiss, A., Beuke, J., Weber, M., Malhotra, A., Behrends, A., Cordes, A., Stille, M., Behr, V. C., Vogel, P., Gräfe, K., Friedrich, T., Lüdtke-Buzug, K., Neumann, A., Ahlborg, M. and Buzug, T. M.: Dynamic 2D Imaging with an MPI Scanner Featuring a Mechanically Rotated FFL, 5, 2019.
  • Beuke, J., Brandt, K., Malhotra, A., Behrends, A., Friedrich, T., Gräfe, K., Rostalski, P. and Buzug, T. M.: Combined Active and Passive Cancellation of Receive Chain Direct Feedthrough, 49, 2019.
  • von Gladiss, A., Blancke Soares, Y., Buzug, T. M. and Gräfe, K.: Dynamic Imaging with a 3D Single-Sided MPI Scanner, 235–236, 2019.
  • Blancke Soares, Y., Gräfe, K., von Gladiss, A., Debbeler, C., Lüdtke-Buzug, K. and Buzug, T. M.: Verification of the Linear System Response of a Single-Sided MPI Device, 51–52, 2019.
2018[ to top ]
  • Weber, M., Beuke, J., von Gladiss, A., Gräfe, K., Vogel, P., Behr, V. C. and Buzug, T. M.: Novel Field Geometry Using Two Halbach Cylinders for FFL-MPI, International Journal on Magnetic Particle Imaging, 4(1), 2018, DOI: 10.18416/IJMPI.2018.1811004.
  • Gräfe, K., von Gladiss, A. and Buzug, T. M.: First Phantom Measurements with a 3D Single Sided MPI Scanner, 2018.
2016[ to top ]
  • Gräfe, K., von Gladiss, A., Ahlborg, M., Bringout, G. and Buzug, T. M.: Reconstruction of a 2D Phantom Recorded with a Single-Sided MPI Device, 23, 2016.
  • Gräfe, K.: Bildgebungskonzepte für Magnetic Particle Imaging Magnetic Particle Imaging mit einer asymmetrischen Spulentopologie, Infinite Science Publishing, Lübeck, 2016, ISBN: 978-3-945954-27-0.
  • Blancke Soares, Y., von Gladiss, A., Ahlborg, M., Gräfe, K. and Buzug, T. M.: Comparison of Frequency Selection Methods for Image Reconstruction in Magnetic Particle Imaging - Improving Image Quality -, 221–224, 2016.
  • Gräfe, K., von Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T.: 2D Images Recorded With a Single-Sided Magnetic Particle Imaging Scanner, IEEE Transactions on Medical Imaging, 35(4), 1056–1065, 2016, DOI: 10.1109/TMI.2015.2507187.
  • Bringout, G., Gräfe, K. and Buzug, T. M.: MPI System Matrix Reconstruction: Making Assumptions on the Imaging Device rather than on the Tracer Spatial Distribution, 174, 2016.
2015[ to top ]
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. and Lüdtke-Buzug, K.: SPIO Detection and Distribution in Biological Tissue - A Murine MPI-SLNB Breast Cancer Model, IEEE Transactions on Magnetics, 51(2), 5400104, 2015, DOI: 10.1109/TMAG.2014.2358272.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T.: Artifacts in field free line magnetic particle imaging, 2015, DOI: 10.1109/IWMPI.2015.7107043.
  • Kaethner, C., Ahlborg, M., Gräfe, K., Bringout, G., Sattel, T. and Buzug, T.: Asymmetric Scanner Design for Interventional Scenarios in Magnetic Particle Imaging, IEEE Transactions on Magnetics, 51(2), 1–4, 2015, DOI: 10.1109/TMAG.2014.2337931.
  • Finas, D., Stegemann-Frehse, J., Sauer, B., Hüttmann, G., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO processing in macrophages for MPI - the breast cancer MPI-SNLB-concept, 228, 2015, DOI: 10.1515/bmt-2015-5010.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T. M.: Artifacts in Field Free Line Magnetic Particle Imaging in the Presence of Inhomogeneous and Nonlinear Magnetic Fields, 2015.
  • Gräfe, K., v. Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T. M.: 2D Imaging with a Single-Sided MPI Device, 2015, DOI: 10.1109/IWMPI.2015.7107024.
  • v. Gladiß, A., Gräfe, K., Ahlborg, M. and Buzug, T.: Undersampling the system matrix of a single sided MPI-scanner, 2015, DOI: 10.1109/IWMPI.2015.7107021.
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. and Buzug, T.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, IEEE Transactions on Magnetics, 51(2), 6502303, 2015, DOI: 10.1109/TMAG.2014.2330371.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T.: Artifacts in field free line magnetic particle imaging in the presence of inhomogeneous and nonlinear magnetic fields, Current Directions in Biomedical Engineering, 1(1), 245–248, 2015, DOI: 10.1515/cdbme-2015-0061.
  • Graeser, M., Ahlborg, M., Behrends, A., Bente, K., Bringout, G., Debbeler, C., v. Gladiß, A., Gräfe, K., Kaethner, C., Kaufmann, S., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Weber, M. and Buzug, T. M.: A Device for Measureing the Trajectorey Dependent Magnetic Particle Performance for MPI, 2015, DOI: 10.1109/IWMPI.2015.7107078.
  • Bringout, G., Gräfe, K. and Buzug, T. M.: Performance and safety evaluation of a human sized FFL imager concept, 37, 2015.
  • Bringout, G., Stelzner, J., Ahlborg, M., Behrends, A., Bente, K., Debbeler, C., von Gladiß, A., Gräfe K., Graeser, M., Kaethner, C., Kaufmann, S., Lüdtke-Buzug K., Medimagh, H., Tenner, W., Weber, M. and Buzug, T. M.: Concept of a Rabbit-Sized FFL-Scanner, 49, 2015.
  • Bringout, G., Gräfe, K. and Buzug, T. M.: Performance of Shielded Electromagnet-Evaluation Under Low-Frequency Excitation, IEEE Transactions on Magnetics, 51(2), 1–4, 2015, DOI: 10.1109/TMAG.2014.2329396.
2014[ to top ]
  • Baumann, K., Stegmann-Frehse, J., Rody, A., Gräfe, K., Lüdtke-Buzug, K., Buzug, T. and Finas, D.: Weiterentwicklung des SNLB-Konzept unter Verwendung von SPIOs beim Mammakarzinom - Prozessierung der Nanopartikel im Organismus, Senologie, 11-A13, 2014, DOI: 10.1055/s-0034-1375372.
  • Kaethner, C., Gräfe, K., Ahlborg, M., Bringout, G., Sattel, T. F. and Buzug, T. M.: Asymmetric Scanner Design for Unlimited Patient Access in Magnetic Particle Imaging, 84–85, 2014.
  • Finas, D., Baumann, K., Stegemann-Frehse, J., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: Processing of nanoparticles in organism - further development of the breast cancer SNLB-concept using SPIOs and MPI, 314, 2014, DOI: 10.1515/bmt-2014-41.
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. F. and Buzug, T. M.: Single-Sided Magnetic Particle Imaging Scanner: System Matrix Measurement, 638–642, 2014, DOI: 10.1515/bmt-2014-5009.
  • Wojtczyk, H., Bringout, G., Tenner, W., Graeser, M., Grüttner, M., Sattel, T., Gräfe, K. and Buzug, T.: Toward the Optimization of D-Shaped Coils for the Use in an Open Magnetic Particle Imaging Scanner, IEEE Transactions on Magnetics, 50(7), 5100507, 2014, DOI: 10.1109/TMAG.2014.2303113.
  • Lindemann, A., Lüdtke-Buzug, K., Fraederich, B. M., Gräfe, K., Pries, R. and Wollenberg, B.: Biological impact of superparamagnetic iron oxide nanoparticles for magnetic particle imaging of head and neck cancer cells, International Journal of Nanomedicine, 9, 5025–5040, 2014, DOI: 10.2147/ijn.s63873.
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. F. and Buzug, T. M.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, 92, 2014.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO detection and distribution in biological tissue – a murine MPI-SNLB breast cancer model, 166, 2014.
  • Kaethner, C., Ahlborg, M., Gräfe, K., Bringout, G., Sattel, T. F. and Buzug, T. M.: On the way to a patient table integrated scanner system in magnetic particle imaging, 903816, 2014, DOI: 10.1117/12.2042765.
2013[ to top ]
  • Kaethner, C., Gräfe, K., Grüttner, M. and Buzug, T. M.: Approximated elliptical coils in magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528343.
  • Gräfe, K., Weber, M., Sattel, T. and Buzug, T.: Precision of an MPI Scanner Construction: Registration of Measured and Simulated Magnetic Fields, 2013, DOI: 10.1515/bmt-2013-4258.
  • Bente, K., Bringout, G., Debbeler, C., Gräfe, K., Graeser, M., Grüttner, M., Kaethner, C., Tenner, W., Weber, M., Wojtczyk, H., Buzug, T. and Lüdtke-Buzug, K.: Magnetic Particle Imaging - eine Einführung in die Instrumentierung und Bildrekonstruktion, 95–100, 2013.
  • Wojtczyk, H., Bringout, G., Tenner, W., Graeser, M., Grüttner, M., Sattel, T., Gräfe, K., Haegele, J., Duschka, R., Panagiotopoulos, N., Vogt, F., Barkhausen, J. and Buzug, T.: Comparison of Open Scanner Designs for Interventional Magnetic Particle Imaging, 2013, DOI: 10.1515/bmt-2013-4279.
  • Gräfe, K., Grüttner, M., Sattel, T., Kaethner, C. and Buzug, T.: Phantom simulation based on measured gradient fields of a single-sided MPI scanner, 2013, DOI: 10.1109/IWMPI.2013.6528352.
  • Gräfe, K., Grüttner, M., Sattel, T. F., Graeser, M. and Buzug, T. M.: Single-sided magnetic particle imaging: magnetic field and gradient, 867219, 2013, DOI: 10.1117/12.2001610.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T.: Lymphatic Tissue and Superparamagnetic Nanoparticles - Magnetic Particle Imaging for Detection and Distribution in a Breast Cancer Model, 2013, DOI: 10.1515/bmt-2013-4262.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T.: Superparamagnetic nanoparticles in lymphatic tissue - Detection and distribution in a breast cancer model for magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528390.
  • Mrongowius, J., Gräfe, K. and Buzug, T. M.: Simulation Study of a Single-Sided Magnetic Particle Imaging Device, 2013, DOI: 10.1515/bmt-2013-4285.
  • Gräfe, K., Mrongowius, J. and Buzug, T. M.: Simulation of a Single-Sided Magnetic Particle Imaging Device with Comsol, 2013.
2012[ to top ]
  • Gräfe, K., Sattel, T., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T.: An Application Scenario for Single-Sided Magnetic Particle Imaging, 514, 2012, DOI: 10.1515/bmt-2012-4343.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Buzug, T. and Lüdtke-Buzug, K.: Detection and distribution of superparamagnetic nanoparticles in lymphatic tissue in a breast cancer model for magnetic particle imaging, 81–83, 2012, DOI: 10.1515/bmt-2012-4158.
  • Buzug, T., Bringout, G., Erbe, M., Gräfe, K., Graeser, M., Grüttner, M., Halkola, A., Sattel, T., Tenner, W., Wojtczyk, H., Haegele, J., Vogt, F., Barkhausen, J. and Lüdtke-Buzug, K.: Magnetic particle imaging: Introduction to imaging and hardware realization, Zeitschrift für Medizinische Physik, 22(4), 323–334, 2012, DOI: 10.1016/j.zemedi.2012.07.004.
  • Finas, D., Baumann, K., Heinrich, K., Ruhland, B., Sydow, L., Gräfe, K., Sattel, T. F., Lüdtke-Buzug, K. and Buzug, T. M.: Distribution of Superparamagnetic Nanoparticles in Lymphatic Tissue for Sentinel Lymph Node Detection in Breast Cancer by Magnetic Particle Imaging, 187–191, 2012, DOI: 10.1007/978-3-642-24133-8_30.
  • Gräfe, K., Sattel, T., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T.: Magnetic-Particle-Imaging for Sentinel Lymph Node Biopsy in Breast Cancer, 237–241, 2012, DOI: 10.1007/978-3-642-24133-8_38.
2011[ to top ]
  • Baas, T., Gräfe, K., Khawaja, A. and Dossel, O.: Investigation of parameters highlighting drug induced small changes of the T-wave’s morphology for drug safety studies, 3796–3799, 2011, DOI: 10.1109/IEMBS.2011.6090769.